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KMID : 0381120220440070889
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Genes and Genomics
2022 Volume.44 No. 7 p.889 ~ p.897
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Association of a novel antisense lncRNA TP73-AS1 polymorphisms and expression with colorectal cancer susceptibility and prognosis
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Fan Jiayao
Xu Huiqing
Liu Bing
Jing Fangyuan
He Qingfang
Zheng Shasha
Shi Haining
Jiao Lefei
Fan Chunhong
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Abstract
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Background: TP73-AS1 is a novel antisense long noncoding RNA and plays an important role in cell proliferation and cancer development. However, the link between TP73-AS1 and colorectal cancer (CRC) has not yet been reported.
Objective: To explore the association of genetic variants in TP73-AS1 and its expression with CRC susceptibility and prognosis.
Methods: A case?control study (including 507 CRC cases and 503 controls) and bioinformatics analysis were conducted.
Results: rs9800 polymorphism was significantly related to higher risk in CRC [adjusted odds ratio (AOR)?=?1.33, 95% confidence interval (CI)?=?1.02?1.75, P?=?0.034 in heterozygote codominant model]. There was no difference between TP73-AS1 polymorphisms and different tumor node metastasis (TNM) stages in the adjusted model. Moreover, TP73-AS1 expression level was positively related to different TNM stages. After adjusted for age, gender and TNM, higher TP73-AS1 expression levels were related to shorter recurrence-free survival time [hazard ratio (HR)?=?1.66, 95% CI?=?1.02?2.71, P?=?0.043].
Conclusion: TP73-AS1 polymorphisms and expression may be associated with susceptibility and prognosis of CRC.
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KEYWORD
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Colorectal cancer, Expression, Long noncoding RNA, Polymorphism, TP73-AS1
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